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Suitable for Rats or Mice, Serial Port Output
The Hot Plate analgesia instrument is for rapid screening of drugs for central analgesic affects. The animal is dropped onto a hot surface as a foot pedal is pressed to start a clock. The observer presses the foot pedal again when the animal makes a stereotyped paw lick response to the hot surface. This latency is strongly affected by analgesic drugs.
Improved DesignTemperature regulation and surface distribution is improved by a 4 mm thick copper plate, held at a setpoint between 30 and 60°C to an accuracy of 0.1°C by multiple proportional feedback circuits that minimize overshoot. The animal's reaction time is recorded to 0.1 sec.
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For Rapid Precise Screening of Analgesic Drugs
The Paw Pressure Analgesia Instrument is for the Randall-Selitto test, which requires the application of increasing pressure on the paw between a flat surface and a blunt pointer. It is usually used with animals with one paw inflamed by an injection, and one normal paw, to evaluate drugs for analgesic action.
For Fast, Sensitive Screening of Analgesic Effects
For Precise Calibration of Infrared Analgesia Meters
Both the 57350 Tail Flick and the 57370 Plantar Analgesia Instruments emit focused infrared beams to provide a heat stimulus to a test animal (e.g., mouse or rat.) The source of the infrared radiation is a commercial tungsten incandescent light bulb.
All bulbs share the property that, for a given electrical current, the amount of light emitted per unit time will gradually decline over the life of the bulb, down to as low as 75% of starting emission. Thus, although it is easy to calibrate an instrument for a specific current flow, this does not determine a specific infrared light stimulus intensity.
Precise Screening of Analgesic Drug Effects - SOFTWARE INCLUDED!
This new, low-cost Hot Plate Analgesia Instrument enables the assessment of the effect of analgesic drugs. This method evaluates the reaction time of mice which are confronted with a heat stimulus applied to the plantar surface.
The heating plate is machined from a pure aluminum slab and connected to thin high-surface heating elements which provide even temperature to the entire test area. The plate temperature can be controlled between 45º C and 62º C, in 0.1º C steps. A built-in timer (0.01 sec steps) activated by an external pedal allows for the precise measurement of the reaction time. The rodent is confined by a clear, removable Perspex cylinder.
Test for Measurement of Paw Pain Inflammation
Digital Screening of Analgesic Drugs - SOFTWARE INCLUDED!
The device exerts steadily increasing force on the rat paw until the animal makes a stereotyped flinch response. This increase is achieved by means of a stepper-motor, which produces a progressive advancement of a sliding support with a conic tip, thus increasing the pressure on the paw.
Measures Paw Sensitivity to heat StimulationThe Plantar™ Analgesia Instrument represents a remarkable advance in methodology for assessing pain sensitivity in laboratory animals. Unique to the Plantar™ Analgesia Instrument, the animal is unrestrained and unhandled. This avoids activating the adrenal system, which by itself can affect pain sensitivity and the speed of the animal's response to pain.
UnrestrainedAnimals move freely (not restrained) on an elevated glass surface. The researcher waits until the animal is at rest, then moves a fiber-optic heat source under the animal's feet, and triggers the infrared beam. The rising temperature on the bottom of the foot will cause the animal to move its foot. This changes the reflected light, which stops the timer. Latency to move the foot is recorded in an automatic (objective) manner.
Fast, Sensitive Screening of Striatal Lesions
Monitoring rotational behavior is important in striatal lesion models and other behaviors. The sensitivity of signal can be adjusted from 4-36 pulses per turn with this device, reliable discriminating even partial turns. Data are additive, providing a comprehensive assessment of turning behavior for both directions. The rotation sensor provides a double (right and left turns) output.
The adjustable Velcro animal harness can be used with a wide range of animals. The harness provides an easily managed fixing support for a connecting wire, for the linking between the animal and the rotation sensor.
For Fast, Sensitive Screening of Analgesic Effects - SOFTWARE INCLUDED!
Stoelting’s Tail Flick Analgesia Instrument is based on the measurement of the latency of the avoidance response when pain is induced by radiant heat applied to the animal’s tail.
The animal is placed on a base and restrained. The base where the animal is placed has a groove to place the tail. When the animal reacts against pain by a sudden tail movement (tail flick), the stimulation stops and the reaction time is measured by a digital clock. Response time is displayed and may be directly exported to a computer for statistical analysis via a serial port. Times are recorded to a 0.1 second accuracy.
The heat stimulus comes from a halogen lamp imbedded in the pivoting stand, and heat intensity can be adjusted from 40°C to 120°C in approximately 10-degree increments (9 different settings).
The system can be used for rats or mice. The heat stimulus can be modified to work with mice or rats (20-400g)
